The Protective Effects of Vernonia Amygdalina, Ocimum Gratissimum and Talinum Triangulare on Cardiac Toxicity in Dichlorvos-Treated Wistar Rats

Authors: Okunima Ambrose, Chukwuma Samuel Anakwe, Aisuodionoe E.M, Okonkwo Browne Chukwudi, Aduloju Richard Akinola

Affiliation: Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Novena University, Ogume, Delta State Nigeria.

Corresponding Author: [email protected]

September 12, 2025

SIAR-Global Journal of Medicine & Pharmaceutical Review

DOI: 10.5281/zenodo.17107559

The Protective Effects of Vernonia Amygdalina, Ocimum Gratissimum and Talinum Triangulare on Cardiac Toxicity in Dichlorvos-Treated Wistar Rats
Research Article Medicine

Abstract

This research assessed the efficacy of Vernonia amygdalina, Ocimum gratissimum, and Talinum triangulare extracts in ameliorating dichlorvos (DDVP)-induced cardiotoxicity. Fifty adult male Wistar rats (272 g) were distributed into ten groups (n=5), including negative and positive controls (saline and 8.0 mg/kg DDVP, respectively), and treatment groups co-administered DDVP with either plant extracts (200 or 400 mg/kg) or vitamin C (20 or 40 mg/kg) for 28 days. DDVP intoxication significantly increased (p < 0.05) cardiac injury biomarkers (LDH and CK). However, all three plant extracts significantly attenuated this rise, demonstrating a dose-dependent protective effect. Histological analysis of cardiac tissue confirmed the biochemical evidence of cardioprotection. These findings indicate that the tested botanicals hold promise as therapeutic agents against pesticide-induced myocardial damage 

Keywords

DDVP, cardiac toxicity, Vernonia amygdalina, Ocimum gratissimum, Talinum triangulare, LDH, Cardioprotective.

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How to Cite

Okunima Ambrose, Chukwuma Samuel Anakwe, Aisuodionoe E.M, Okonkwo Browne Chukwudi, Aduloju Richard Akinola (2025). The Protective Effects of Vernonia Amygdalina, Ocimum Gratissimum and Talinum Triangulare on Cardiac Toxicity in Dichlorvos-Treated Wistar Rats. SIAR-Global Journal of Medicine & Pharmaceutical Review, Vol. 1, No. 1. DOI: 10.5281/zenodo.17107559

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Article Information

  • Type: Research Article
  • Journal: SIAR-Global Journal of Medicine & Pharmaceutical Review
  • Subject Area: Medicine
  • Published: September 12, 2025
  • Volume: 1
  • Issue: 1
  • Word Count: Not specified
  • DOI: 10.5281/zenodo.17107559
  • Processing Fee: $50.00 USD

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SIAR-Global Journal of Medicine & Pharmaceutical Review

The SIAR-Global Journal of Medicine &amp; Pharmaceutical Review (GJMPR) is an official medical and health science publication of the Society …

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